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Of the 1678 records reviewed, 17 studies met inclusion criteria (10 case reports, 1 retrospective cohort study, 5 cross-sectional studies, 1 interventional study). Most case reports described people with BD switching to manic, hypomanic or mixed states after consuming caffeine in variable amounts and/or whose serum lithium concentrations increased after reducing caffeine consumption. The interventional study found that caffeine may suppress lithium concentrations, while the retrospective cohort study reported that participants who drank coffee had more suicidality than non-drinkers.

Acute increases in caffeine consumption may precede the occurrence of manic symptoms in patients with BD, potentially through a direct stimulant effect, affecting sleep patterns and/or the metabolism of lithium or other medications, although increases in caffeine intake could also be a consequence of an ongoing manic relapse or a prodromal sign. 
#bipolardisorder
GRAVITY8
GRAVITY9

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2 GRAVITY

コーヒーそれだけでmanicになるし睡眠不足にもなるしリチウムの血中濃度下げるしやべえじゃん でもコーヒー好きだからのむお

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ラーメンチャツネ
ラーメンチャツネ
因果関係分かんないっすね…。とはいえRCTなんて倫理的にアウトど真ん中でヤバ杉…。 (外的妥当性という点に関しては、自分が何を、どの位の量を、いつ飲むか、避けるタイミングはいつかなど摂取の具体的判断は主治医との相談、ケースバイケース、といったところですかね。)
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タコ🐙ボウズ☘️

タコ🐙ボウズ☘️

1 GRAVITY

あぁーーーーーーはぁん[穏やか]

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ピン留めコメに要約のっけてます[照れる]
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Of the 1678 records reviewed, 17 studies met inclusion criteria (10 case reports, 1 retrospective cohort study, 5 cross-sectional studies, 1 interventional study). Most case reports described people with BD switching to manic, hypomanic or mixed states after consuming caffeine in variable amounts and/or whose serum lithium concentrations increased after reducing caffeine consumption. The interventional study found that caffeine may suppress lithium concentrations, while the retrospective cohort study reported that participants who drank coffee had more suicidality than non-drinkers.